Prevalence of Virulence Genes and Drug Resistance Profiles of Pseudomonas aeruginosa Isolated From Clinical Specimens

Background: Drug resistance and virulence genes are two key factors for the colonization of Pseudomonas aeruginosa in settings with high antibiotic pressure, such as hospitals, development hospital-acquired infections. Objectives: The objective this study was to investigate prevalence drug gene profiles clinical isolates P. Ardabil, Iran. Methods: A total 84 were collected from specimens Ardabil hospitals confirmed using laboratory standard tests. disk diffusion method used susceptibility testing polymerase chain reaction (PCR) identification genes. Results: highest lowest rates strains against ticarcillin-clavulanate (94%) doripenem (33.3%), respectively. In addition, frequency multidrug-resistant (MDR) 55.9%. factor follows: algD 84.5%, lasB 86.9%, plcH plcN exoU 56%, exoS 51.2%, toxA 81%, nan1 13.1%, pilB 33.3%. significant association observed between some antibiotics aeruginosa. Conclusions: Our results revealed a resistance, especially MDR, virulence-associated hospitals. Owing low doripenem, gentamicin, tobramycin, these recommended treatment infections caused by highly resistant virulent strains.